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Thursday, July 3, 2025

Wolf-Kishner reduction: Reduction of carbonyl into alkane with hydrazine in high boiling solvent such as glycol .

This reaction is not preferred when base sensitive groups like halogens  or bulky groups are present.

Clemmensen reduction: reduction of an aldehyde or a ketones with zinc amalagam and concentrate Hydrochloric (HCl) acid.

Note; Clemmensen reduction not  suitable for those compound having acid sensitive groups ( basic in nature) such as  Alcohol, amines, alkenes, ester, cyclic ketal, nitro etc.