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Friday, January 24, 2020

How write mechanism of exhaustive methyl and Hoffmann elimination of ethanamine?


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What is mechanism of exhaustive methylation and Hoffmann elimination of piperidine a secondary amine?

This reaction can be used to determine the structure of amines especially in complex molecules such as alkaloids.
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Explain Exhaustive alkylation and Hoffmann Elimination.

Then reaction of amines with excess of alkyl halides to form a quaternary ammonium salt is known as exhaustive alkylation and if the alkyl group is methyl, then it is known as exhaustive methylation .
The exhaustive methylation of amine followed by treatment with moist silver oxide (AgO + O2--> AgOH) and subsequent heating to form alkene is known as Hoffmann elimination.

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