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Friday, January 24, 2020

What is difference between Houben–Hoesch acylation reaction and Gatter- mann–Koch formylation reaction?

Houben–Hoesch reaction ia an analogous reaction  of Gatter-mann–Koch reaction, it is sometimes called the Hoesch reaction.
Houben–Hoesch reaction:

Hoesch reaction is basically FACT acylation of aromatic compounds with nitriles and HCl.
Gatter-mann–Koch reaction:
Gatter-mann–Koch reaction is formulation of benzene ring in the presence of CO and HCl.

How write mechanism of exhaustive methyl and Hoffmann elimination of ethanamine?


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What is mechanism of exhaustive methylation and Hoffmann elimination of piperidine a secondary amine?

This reaction can be used to determine the structure of amines especially in complex molecules such as alkaloids.
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Explain Exhaustive alkylation and Hoffmann Elimination.

Then reaction of amines with excess of alkyl halides to form a quaternary ammonium salt is known as exhaustive alkylation and if the alkyl group is methyl, then it is known as exhaustive methylation .
The exhaustive methylation of amine followed by treatment with moist silver oxide (AgO + O2--> AgOH) and subsequent heating to form alkene is known as Hoffmann elimination.

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What is Imine-Enamine tautomerism?

An imine is a compound that contains a -C=NH bond. It is homologous of -C=O. And Imime form is just similar to keto form and Enamine form is just similar to Enol form . The Imine-Enamine tautomerism is due to the migration of alpha hydrogen from one polyvalent atom to another to form Enamine thus Imines can be converted into enamines.

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