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Saturday, July 5, 2025

Williamson's Synthesis.

⇒It is the laboratory method for the preparation of ethers. 

⇒It is a nucleophilic substitution reaction and proceeds through the SN2 mechanism.
⇒ Order of reactivity of primary halide is CH3X > CH3CH2X > CH3CH2CH2X. 
⇒ Tendency of alkyl halide to undergo elimination is 3º > 2º > 1°. 

⇒ For better yield alkyl halide should be primary and alkoxide should be secondary or tertiary. 

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