Welcome to ChemZipper !!!: Out of Acet.yl chloride and acetic anhydride, acetic anhydride is preferred for acylation reactions. Explain why?

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Out of Acet.yl chloride and acetic anhydride, acetic anhydride is preferred for acylation reactions. Explain why?

Both acetyl chloride and acetic anhydride are good acetylating agents, however, acetyl chloride is much more reactive than acetic anhydride and hence with acetyl chloride reactions are very fast and difficult to control , and with acetic anhydride can be controlled easily. Therefore, acetic anhydride is preferred over acetyl chloride for acetylation.

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